ABSTRACT
Objective To analyze and assess the postoperative motor function in children with spastic cerebral palsy (SCP) by surface electromyography (sEMG) and joint angle. Methods Sixteen children with SCP were involved in this study. The sEMG of rectus femoris, biceps femoris, semitendinosus, tibialis anterior, lateral gastrocnemius and medial gastrocnemius muscles and joint angles of the hip, knee and ankle during straight walking were collected preoperatively and postoperatively. In every gait phase, the mean values of joint angles, root mean square and integrated electromyography of sEMG were calculated, to evaluate muscle strength and muscular tension quantitatively. Results The muscle tension of lower limbs was significantly decreased (P<0.05). The muscle strength of rectus femoris and biceps femoris was decreased in the swing phase. At the midswing and terminal swing phase, the strength of tibialis anterior increased significantly (P<0.05). The flexion angle of hip and knee decreased significantly (P<0.05). The dorsiflexion angle of ankle increased significantly (P<0.05), and the varus angle decreased significantly (P<0.05). Conclusions After operation, the crouching gait and clubfoot were improved positively. Therefore, the motor function of children was improved. Combining sEMG and joint angle can evaluate the muscle function of patients quantitatively, and it also can provide references for clinical diagnosis.
ABSTRACT
Objective Toinvestigate the expression and clinical significance of Survivin and Glut 1 protein in gastric carcinoma.Methods In 78 gastric carcinoma specimen and 20 normal mucosa gastric specimen,the expression of Glut 1 and Survivin protein was detected by immunohistochemistry.The relationship between expression of Survivin and Glut 1 protein and clinical pathological parameters were analyzed.Results The rates of Survivin and Glut 1 protein expression were 75.64％ (59/78) and 78.21％ (61/78) respectively,which were significantly higher than those in normal gastric tissues(10.00％ (2/20) and 5.00％ (1/20),x2 =4.265,4.158,P ＜ 0.01).The expression of Survivin protein was not related to gender and age (P ＞ 0.05),but was associated with cellular differentiation,serosa infiltration,lymph node metastasis and TNM stage (x2 =4.143,4.247,11.813,7.542,P ＜ 0.05).The expression of Glut 1 protein was not related to gender,age,cellular differentiation and serosa infiltration (P ＞ 0.05),but was associated with lymph node metastasis and TNM stage(x2 =6.230,4.083,P ＜ 0.05).The expression of Survivin protein was positively correlated with Glut 1 protein(x2 =7.145,r =0.342,P ＜0.05).Conclusion Elevated levels of Survivin and Glutl protein play an important role in the carcinogenesis and development of gastric carcinoma.The measurement of Survivin and Glut 1 protein levels may be effective parameters for predicting the biological behavior and prognosis of gastric carcinoma patients.